HomeMain DishesCajun Shrimp Lasagna Roll-Ups
Cajun Shrimp Lasagna Roll-Ups
These Lasagna Roll-Ups are fabulously rich and creamy with shrimp in every bite!
- Prep20 min
- Cook30 min
- Total50 min
- Serves8
- Rating5.0

Cajun Shrimp Lasagna Roll-ups are wonderfully spicy, rich, and creamy. It’s a southern twist on lasagna that’s worthy of a special occasion.

Lots of cheese, Andouille sausage, and spice makes this a meal to remember. These lasagna roll-ups are loaded with shrimp. There’s one in every bite!
As with any lasagna recipe, this one takes a little time and effort, but it is so worth it for a special occasion. Leftovers reheat well and a smaller family could totally get 2 even 3 meals out of them so I think it is time well invested.
Just enter your email and get it sent to your inbox! Plus you’ll get new recipes from us every week!Please enable JavaScript in your browser to complete this form.Name *Email *
Variations
- Try using a combination of shrimp and crab or shrimp and crawfish.
- You could sub half the cheese with mozzarella cheese.
Tips For Making Cajun Shrimp Lasagna Rolls
- They can be assembled a day in advance and covered in plastic wrap and refrigerated. Just add a few minutes to the baking time.
- They only take 30 minutes in the oven, so much quicker to cook than a regular lasagna. Be sure to spray the underside of the foil with cooking spray when you cover them so it doesn’t get stuck to the cheese.
- Be sure to undercook the shrimp slightly when you make the filling or they may overcook in the oven.
Storage
Shrimp are really perishable so I don’t like to keep leftovers for more than 2 to 3 days. Store in an airtight container in the refrigerator.

Pin this now to find it later
More Shrimp Recipes
- Bang Bang Shrimp Pasta
- Spicy Shrimp and Tomato Cream Pasta
- Spicy Shrimp Dip
- Easy Shrimp Creole
- New Orleans-Style BBQ Shrimp
- Buttery Broiled Shrimp

Disclosure: This post contains affiliate links.
Ingredients
Steps
- 1
Heat olive oil over medium-high heat in a large nonstick skillet. Add sausage and onion and cook until sausage is browned and onion is soft.
- 2
Add garlic, shrimp, diced tomatoes, and Cajun seasoning and cook until shrimp just turn pink. They will cook more in the oven so you want them slightly undercooked at this point. Drain off any excess liquid and stir in cottage cheese. Set aside.
- 3
In a medium saucepan, melt 1/4 cup of butter. Add flour and cook and stir for 1 minute. Gradually whisk in milk. Bring to a simmer for a few minutes to thicken.
- 4
Remove sauce from heat and stir in cheddar cheese until melted.
- 5
Grease a casserole dish. I use one that is a little smaller than 9x13-inch. A 7x11-inch will work. You don't want extra space or the filling will ooze out. Preheat oven to 350 degrees.
- 6
Spread about 1/2 cup shrimp filling on each noodle and carefully roll up. Place in prepared pan seam side down. If any filling falls out, just tuck it back in. The roll-ups should be very close together.
- 7
If there is extra filling spoon it on top.
- 8
Pour cheese sauce evenly on top. Sprinkle with Pepper Jack cheese. Cover with foil and bake for 15 minutes. Uncover and bake 15 more minutes. Tip: Spray underside of foil with cooking spray so it will not stick to the cheese.
Notes
You could sub half the cheese with mozzarella cheese.
Nutrition
- Calories573
- Carbs34
- Protein40
- Fat31
- Sodium767
- Fiber2
- Sugar8
More from this shelf
Main DishesInstant Pot Jalapeno Popper Shredded Chicken
Main DishesCaramelized Onion Meatloaf
Main DishesRanch Seasoned Fried Pork Chops
Main DishesCrock Pot Chicken and Noodles
Main DishesBaked Bourbon Teriyaki Chicken
Main DishesSouthern Fried Pork Chops
Main DishesBBQ Spaghetti Casserole
Main DishesBasil, Chicken, and Green Beans in Coconut Curry Sauce